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Popular flu treatments in Spain under review due to risk of brain diseases

Popular flu treatments in Spain under review due to risk of brain diseases


The European Medicines Agency is reviewing hundreds of medications containing pseudoephedrine - including Termalgil, Frenadol, and Cinfatós


Friday, 24 February 2023

The European Medicines Agency (EMA) has put hundreds of medicines containing pseudoephedrine under review, which is a very commonly used drug to treat colds or flu. The agency's safety committee has targeted the products because of a possible risk of brain diseases such as posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS), which affect blood vessels.

Pseudoephedrine is a very common pharmacological agent taken orally and is present in some of the most commonly sold brand names in pharmacies. From the list provided by the EMA on products under surveillance, about thirty are marketed in Spain, including well-known ones such as Termalgil, Gelocatil Influenza with pseudoephedrine, Frenadol Descongestivo or Cinfatós.

According to information released by the EMA, PRS and RCVS cause reduced blood supply (known as ischemia) to the brain and can cause serious and life-threatening complications in some cases. The most common symptoms are headache, nausea and convulsions.

The EMA is to decide whether or not to maintain the marketing of these drugs, modify them or withdraw them from the market.

The full list of the medicines under review with pseudoephedrine in Spain is as follows:


-Narine Repetabs

-Clarityne Plus

-Lasa with Codeine

-Pseudoephedrine Farmalider

-Gelocatil Influenza with Pseudoephedrine

-Termalgin Cold

-Frenadol Decongestant



-Inistolin Pediatric Cough and Congestion

-Iniston Mucus and Congestion

-Iniston Cough and Congestion

-Grippal with Pseudoephedrine and Dextromethorphan



-Cinfatós Decongestant

-Respidina Expectorant Junior

-Cinfatós Comple



-Respidine Antiallergic


-Vincigrip Forte Cocoa Flavor

-Vincigrip Forte Orange Flavor


-Virlix Plus

-Ibuprofen/Pseudoephedrine Nutra Essential


-Cortafriol C




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